What do you like to do? Give us some ideas and we'll give you more specific suggestions!
The Mission Inn is nice (and historic, too) -- and there is a Disney tie in (part of the inspiration for the lobby in Tower of Terror), but there isn't much else to do in that area and, IMO, there aren't many nice places to eat. Just my opinion, but it's a long drive for just one destination. But, you can look up the Mission Inn's website to see if it looks like something you'd like to do.
The beach can work out, depending on why you want to go. If you want swimming and sunbathing, then it will be hit or miss. But if you just want to walk around, do some shopping, eat at some fun places -- that can work just fine. Huntington Beach and Newport Beach aren't far away. La Jolla is nice, if you want to go further from Anaheim. And Venice Beach is definitely memorable. (Siggy can fill you in if you want more details on Venice.) If you want the beach and another theme park, you can look at Legoland in Carlsbad (closer than La Jolla, but still a longer drive than the other beaches). Legoland will be just right for your toddler. And Carlsbad has an outdoor outlet mall and an old town section with restaurants.
If you like shopping, Fashion Island is a really pretty, outdoor mall in Newport Beach. They always have a really big Christmas tree. Combined with Newport Beach itself, that could be a fun day.
And, don't forget the Walt Disney Archives exhibit at the Ronald Reagan Library in Simi Valley. It is not close to Anaheim, but if you time your drive to avoid rush hour, the drive isn't too bad. Not sure how appropriate this would be for your toddler, but the Reagan Library has lovely grounds, 2 eateries, Air Force One, and other exhibits. If you like Disney history and artifacts, this is a great exhibit.
And, if you don't mind more crowds, you can visit Pasadena to see the Rose Parade floats. They will be on display for a day or two after the parade in a park (forget which one, but it must be on the Tournament of Roses website). There is lots to do in Old Town Pasadena, too. And there is the Huntington Library, if you like gardens.
Hope this info helps!
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