My email is overrun with Mousepad responses. I've tried to edit my options, but nothing is working. What exactly do I need to do???
Thank you

Go to UserCP and unsubscribe the numerous threads that are in your subscription list. At the same time, you may want to set the defaults (Under EDIT OPTIONS) to not automaticly add a replied-to thread to the subscription list. You can then pick and choose when you want to sub to a replied message.

(I had this same problem to for a while...)